Release Time: 2021-08-04
Not after a very cold test, can't smell the fragrance of the plum blossom?
In 2020, Affected by COVID-19, all walks of life have suffered unprecedented hardships.
In this unprecedented adversity, the scientific research team of Bontac Bio-engineering (Shenzhen) Co., Ltd. is still working hard and forging ahead. We have successively obtained 4 patent certificates issued by the Japan Trademark and Patent Office, the U.S. Patent and Trademark Office, and the State Intellectual Property Office of China.
These are the 4 new patents recently obtained by Bontac after accumulating more than 150 patent applications. Such impressive achievements in scientific research are undoubtedly the best commendation for the innovative spirit of Bontac.
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Invention Title: A mutant of nicotinamide phosphoribosyltransferase and its application
Technical advantages: Compared with the existing wild-type nicotinamide phosphoribosyltransferase, the enzyme activity of the nicotinamide phosphoribosyltransferase mutant provided by the present invention is greatly improved. the enzyme activity showed that when using nicotinamide and PRPP as substrates, the catalytic activity of the nicotinamide phosphoribosyltransferase mutant provided by the present invention is 1.2-6.9 times higher than its parent. Such high catalytic activity enables it to be used as a crude enzyme without purification, or only partially purified. This greatly reduces the cost of using the nicotinamide phosphoribosyltransferase mutant provided by the present invention to catalyze the production of NMN, and has high market competitiveness. And it can meet the needs of applying NMN's biocatalytic method to large-scale industrial production.
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Invention Title: Purification Process of NADPH
Technical advantages: Compared with the prior art, the NADPH purification process provided by the present invention has the advantages of high yield and high purity of the purified product. Industrial practice has proved that the yield of the purification process can reach more than 85%, and the purity of purified NADPH is as high as 98%. In addition, the process does not use toxic and harmful organic solvents, is environmentally friendly, is simple and easy to operate, and has low production costs, making the purified product extremely competitive in the market. The process has universal applicability for the purification of the crude NADPH product obtained by the biocatalytic method for preparing NADPH.
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Invention Title: A Purification Method of Ginsenoside Rh2
Technical advantages: Compared with the prior art, the purification method of ginsenoside Rh2 provided by the present invention has the advantages of simple operation, short time-consuming and low cost. The method only needs to use a small amount of extractant to obtain high yield and purity of ginsenoside monomer Rh2 after one-time extraction, and the obtained purified product is extremely competitive in the market.
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Invention Title: Rh2 enzymatic large-scale production system
Technical advantages: Compared with the existing production system, the Rh2 enzymatic large-scale production system provided by the present invention has the advantage of simple structure, complete functions, compact arrangement, space and cost saving, automatic control of temperature and pH value, and labor saving. In addition, a separate water washing kettle and corresponding solid-liquid separation device can be set up to realize continuous and uninterrupted reaction of two batches of materials.
Bontac has always attached importance to the development of new technologies and the cultivation of independent intellectual property rights. Since its establishment, the company has accumulated nearly 160 independently developed enzyme catalysis-related invention patents and international patent applications, and has its own enzyme library and more than 600 strains. Bontac Bio-engineering has the research and development capabilities of professional enzyme screening, gene repair, and enzyme immobilization, and its products have been widely used in industrial pharmacy, diagnostic reagents and other fields.
2021, Bontac will have more patent incubation Plan, Please Look Forward To!